PhysicsResearchScience

Scientific Debate Emerges Over Casimir Force Measurements in Micro-Scale Cavity Experiments

A scientific controversy has emerged regarding the measurement of strong attractive forces in micrometre-sized narrow-gap cavities. Experimental researchers claim theoretical calculations using proximity force approximation fail to match their observed results due to geometric differences in the models.

Experimental Findings Challenge Theoretical Predictions

Scientific reports indicate a significant discrepancy between theoretical predictions and experimental measurements of attractive forces in micrometre-scale re-entrant cavities. According to sources familiar with the research, experimental teams have detected force magnitudes that cannot be adequately explained by current Casimir force calculations using proximity force approximation (PFA) methods.

HealthcareResearchScience

TDP-43 Dysfunction Triggers Widespread Genetic Processing Errors in Neurodegenerative Diseases, Study Reveals

Scientists have discovered that loss of TDP-43 protein from cell nuclei triggers widespread errors in genetic processing in neurodegenerative diseases. The findings reveal how alternative polyadenylation changes contribute to frontotemporal dementia and ALS pathology through multiple disease-relevant genes.

Breakthrough Study Reveals Genetic Processing Errors in Neurodegenerative Diseases

Researchers have uncovered a crucial mechanism by which TDP-43 protein dysfunction contributes to frontotemporal dementia and amyotrophic lateral sclerosis, according to a new study published in Nature Neuroscience. The report indicates that loss of TDP-43 from neuronal nuclei causes widespread changes in alternative polyadenylation (APA), a fundamental genetic processing mechanism that determines where RNA molecules are cut and adding a tail of adenine nucleotides.